Hmm, two-disk Numen worked for me -- PAL 320K Rambo mode.

http://www.virtualdub.org/beta/Altirra-2.20-test5.zip
http://www.virtualdub.org/beta/Altirra-2.20-test5-src.zip

Has the MyIDE 4.10 fix and rewritten keyboard/menu code. Option | Keyboard Shortcuts now allows you to rebind the command-based keys on the keyboard. Currently, this is all of them except the ones that correspond to Atari keys (F2:Start, F3:Select, F4:Option, F6:Help, F7:Break); these still cannot be reassigned yet although you can override them. You can bind to any command on the menu. For instance, binding Display:F7 to System.ToggleWarpSpeed will get A8WP-style speed toggling. The framework is also in place to allow the menu to be edited although there is currently no UI for doing so.

I had to redo the menus from scratch, so it´s possible I might have broken some commands. If some of the items don´t work or don´t highlight correctly, let me know so I can fix them up.